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Medicinal-Pharmaceutical Chemistry Commons

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Synthetic Approaches To Huperzine A , Danette René Vines Jan 1994

Synthetic Approaches To Huperzine A , Danette René Vines

Retrospective Theses and Dissertations

The natural product huperzine A has been found to possess activity as a nootropic agent. Because of its memory facilitating effects, huperzine A represents a promising drug for the treatment of neurodegenerative diseases, such as Alzheimer's disease. As life expectancy increases, identifying and synthesizing drugs which treat cognitive dysfunction becomes a primary health objective;This study was undertaken to synthesize huperzine A, and to offer a direct route to improved analogs of huperzine A. A bicyclic amino ketone for the synthesis of huperzine A was prepared in six steps. The conjugate addition of metallated alkylpyridines afforded a direct route ...


Synthesis, Structure Features And Application Of Pro-Azaphsphatranes As Catalysts And Strong Non-Ionic Bases In Organic Synthesis , Jiansheng Tang Jan 1994

Synthesis, Structure Features And Application Of Pro-Azaphsphatranes As Catalysts And Strong Non-Ionic Bases In Organic Synthesis , Jiansheng Tang

Retrospective Theses and Dissertations

This dissertation describes the development of pro-azaphosphatranes ZP(MeNCH[subscript]2CH[subscript]2)[subscript]3N as versatile useful materials in organic synthesis;Pro-imidophosphatranes MeN= P(MeNCH[subscript]2CH[subscript]2)[subscript]3N and PhN= P(MeNCH[subscript]2CH[subscript]2)[subscript]3N, their corresponding acyclic analogues MeN= P(NMe[subscript]2)[subscript]3 and PhN= P(NMe[subscript]2)[subscript]3, and their conjugate acids as well as the conjugate acid of the commercially available non-ionic base P[subscript]4-t-Bu (i.e. t-BuN=P (N=P(NMe[subscript]2)[subscript]3][subscript]3) have been synthesized. Equilibria measured by [superscript ...


Highly Reactive Forms Of Zinc And Reagents Thereof, Reuben D. Rieke Jan 1994

Highly Reactive Forms Of Zinc And Reagents Thereof, Reuben D. Rieke

Faculty Publications -- Chemistry Department

A novel zerovalent zinc species and an organozinc reagent are disclosed. The zerovalent zinc species is directly produced by reaction of a reducing agent on a zinc salt, preferably Zn(CN)2. The organozinc reagent results from the reaction of the zerovalent zinc species and an organic compound having one or more stable anionic leaving groups. These organozinc reagents include a wide spectrum of functional groups in the organic radical, and are useful in a variety of reactions schemes.