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Medicinal-Pharmaceutical Chemistry Commons

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Use Of Affinity Chromatography In Developing Acridinium Ester-Labeled Antibodies For An Immunometric Assay Of Parathyrin, David S. Hage, Bob Taylor, Pat Schryver, Pai C. Kao Jan 1991

Use Of Affinity Chromatography In Developing Acridinium Ester-Labeled Antibodies For An Immunometric Assay Of Parathyrin, David S. Hage, Bob Taylor, Pat Schryver, Pai C. Kao

David Hage Publications

In developing an immunometric assay of intact parathyrin (parathyroid hormone, PTH), we found that affinity chromatography is a useful tool in purifying and optimizing the labeling conditions for acridinium ester-labeled antibodies. ... In summary, affinity chromatography was found to be useful in the purification of acridinium ester-labeled antibodies, particularly for removing denatured antibodies from the prepared label and for monitoring the amount of active labeled antibodies produced.


Development Of An Ocular Drug Release System For Cattle , Thomas Quang Dinh Jan 1991

Development Of An Ocular Drug Release System For Cattle , Thomas Quang Dinh

Retrospective Theses and Dissertations

An erodible ring-shaped ocular insert containing an antibiotic (tylosin tartrate) has been developed for treatment of infectious bovine keratoconjunctivitis (IBK). Four additional tasks have been completed: (1) a test to determine the retention time of the ocular device in the eyes of the calves, (2) an in vitro test to determine the degradation characteristics of the device, (3) an in vitro study to obtain the drug release profiles of the insert, and (4) a study to compare the use of rings and a field treatment method using infected cattle;The device remained in the eyes an average of 3.92 ...