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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Preparation Of Pvp-Coated Copper Oxide Nanosheets As Antibacterial And Antifungal Agents, Mahdi Shahmiri Oct 2013

Preparation Of Pvp-Coated Copper Oxide Nanosheets As Antibacterial And Antifungal Agents, Mahdi Shahmiri

mahdi shahmiri

Copper oxide (CuO) nanosheets synthesized in polyvinylpyrrolidone (PVP) were characterized with respect to antimicrobial activity by quick precipitation method. Different sizes and shapes of CuO nanosheets were obtained by simple variations of PVP concentrations. The x-ray diffraction results revealed the formation of pure-phase CuO with monoclinic structure. Transmission electron microscopy analysis showed that the average ratio of length to width of these nanosheets increased with increasing PVP concentrations. Due to the quantum size effect, CuO nanosheets exhibit a blue shift in the ultraviolet-visible spectra. Field emission scanning electron microscopy results showed that as the concentration of PVP increased, well-defined morphologies ...


Synthesis, Physicochemical Properties, And In Vitro Antibacterial Screening Of Palladium(Ii) Complexes Derived From Thiosemicarbazone, Mohammad Oves Jun 2013

Synthesis, Physicochemical Properties, And In Vitro Antibacterial Screening Of Palladium(Ii) Complexes Derived From Thiosemicarbazone, Mohammad Oves

Mohammad Oves

No abstract provided.


Butylated Hydroxytoluene Analogs: Synthesis And Evaluation Of Their Multipotent Antioxidant Activities, Azhar Ariffin Jan 2012

Butylated Hydroxytoluene Analogs: Synthesis And Evaluation Of Their Multipotent Antioxidant Activities, Azhar Ariffin

Azhar Ariffin

A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS) program. Antioxidant activity of compounds 1, 3, 4 and 5 were studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and lipid peroxidation assays to verify the predictions obtained by the PASS program. Compounds 3 and 5 showed more inhibition of DPPH stable free radical at 10(-4) M than the well-known standard antioxidant, butylated hydroxytoluene (BHT). Compound 5 exhibited promising in vitro inhibition of Fe2+-induced lipid peroxidation of the essential egg yolk as a lipid-rich medium (83.99%, IC50 16.07 +/- 3.51 mu M/mL ...


N-Acetyl-2-Hydroxy-N '- Methoxy(1-Methylindol-2-Yl)Methyl Benzohydrazide, Azhar Ariffin, Ng S. W., Yehye W. A., Rahman N. A. Jan 2008

N-Acetyl-2-Hydroxy-N '- Methoxy(1-Methylindol-2-Yl)Methyl Benzohydrazide, Azhar Ariffin, Ng S. W., Yehye W. A., Rahman N. A.

Azhar Ariffin

In the crystal structure of the title Schiff-base, C(20)H(21)N(3)O(4), the amino group forms an N-H center dot center dot center dot O hydrogen bond to the acetyl group of an adjacent molecule, forming a zigzag chain. The 2-hydroxy group is internally hydrogen bonded to the amido group though an O-H center dot center dot center dot O hydrogen bond.