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Medicinal-Pharmaceutical Chemistry Commons

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Seton Hall University Dissertations and Theses (ETDs)

Dissolution

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Understanding The Dynamic Process Of Dissolution Using In-Situ Ft-Ir Spectroscopy, Vrushali M. Bhawtankar May 2017

Understanding The Dynamic Process Of Dissolution Using In-Situ Ft-Ir Spectroscopy, Vrushali M. Bhawtankar

Seton Hall University Dissertations and Theses (ETDs)

Dissolution studies provide valuable and critical drug release information (in vitro) that are important for quality control drug development. Using in-situ FT-IR spectroscopy methods has been developed for analyzing and monitoring dissolutions of pharmaceutical APIs. The accuracy of this technique was found to be ± 3% relative to HPLC and UV/Vis Spectroscopy. A dynamic analysis of the dissolution and subsequent hydrolysis of aspirin has been determined by in-situ FT-IR. This technique allows real-time analysis of the behavior of aspirin under simulated physiological conditions (pH 1.2, 4.5, 6.8) as aspirin (1205 cm-1) and salicylic acid (1388 cm ...


Monitoring Dissolution Of Nonsteroidal Anti-Inflammatory Drugs Using Infrared Spectroscopy, Julianne Berger May 2015

Monitoring Dissolution Of Nonsteroidal Anti-Inflammatory Drugs Using Infrared Spectroscopy, Julianne Berger

Seton Hall University Dissertations and Theses (ETDs)

A comparison study was conducted to look at the formulation of three brands of naproxen sodium. These brands included Bayer Aleve ®, CVS All Day Pain Relief and Walgreens All Day Pain Relief. The active and inactive ingredients were the same yet the size and shape of the tablets differ among the three brands. S-naproxen was extracted from the tablets and evaluated by GC-MS to determine the purity of naproxen in the tablets. Dissolution was monitored by an IR probe for eight hours while using 0.1M phosphate buffer pH 7.4, 0.05M phosphate buffer pH 4.5 and simulated ...