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Medicinal-Pharmaceutical Chemistry Commons

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Chemistry Articles

2015

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Stable Poly(Methacrylic Acid) Brush Decorated Silica Nano-Particles By Arget Atrp For Bioconjugation, Marcello Iacono, Andreas Heise Jan 2015

Stable Poly(Methacrylic Acid) Brush Decorated Silica Nano-Particles By Arget Atrp For Bioconjugation, Marcello Iacono, Andreas Heise

Chemistry Articles

The synthesis of polymer brush decorated silica nano-particles is demonstrated by activator regeneration by electron transfer atom transfer radical polymerization (ARGET ATRP) grafting of poly(tert-butyl methacrylate). ATRP initiator decorated silica nano-particles were obtained using a novel trimethylsiloxane derivatised ATRP initiator obtained by click chemistry. Comparison of de-grafted polymers with polymer obtained from a sacrificial initiator demonstrated good agreement up to 55% monomer conversion. Subsequent mild deprotection of the tert-butyl ester groups using phosphoric acid yielded highly colloidal and pH stable hydrophilic nano-particles comprising approximately 50% methacrylic acid groups. The successful bio-conjugation was achieved by immobilization of Horseradish Peroxidase to ...