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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Systematic Synthesis And Study Of The Structure-Property Relationships Of Arylene Vinylene Polymers., Patrick Lynch Jan 2008

Systematic Synthesis And Study Of The Structure-Property Relationships Of Arylene Vinylene Polymers., Patrick Lynch

Doctoral

Much is known about the electronic, vibrational and steric effects resulting from the addition of differing organic functional groups as side chains, to the parent conjugated polymer. However the same cannot be said about the substitution of constituents of the polymer backbone itself. To this end a study is presented here which systematically studies the effects of naphthalene and anthracene substitution of the properties of poly phenylene vinylene (PPV) derivative conjugated polymers. The synthesis by the Witting-Horner reaction of derivatives is presented whereby the phenylene units of the PPV structure are methodically substituted by naphthylene and anthrylene units to form ...


Metallo-Cyclodextrin Complexes For The Separation Of Chiral Materials, Synthesis And Characterisation, Ciaran Francis Potter Jun 2007

Metallo-Cyclodextrin Complexes For The Separation Of Chiral Materials, Synthesis And Characterisation, Ciaran Francis Potter

Doctoral

The processes of separation and detection of chiral compounds are extremely important in the pharmaceutical industry. This study aims to investigate a safe and variable methods for the separation of the two enantiomers of the drug DOPA (Dihydroxyphenylalanine). L-DOPA is the most effective drug at present used to combat Parkinson’s disease while D-DOPA is inactive, thus for drug efficacy only the single biologically active enantiomer should be present in the formulation. In this work, cyclodextrins (CDS) were utilised fro their ability to act as a host for guest species, acting in the role as both a first and second ...