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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

In Vitro Label Free Screening Of Chemotherapeutic Drugs Using Raman Micro-Spectroscopy: Towards A New Paradigm Of Spectralomics., Zeineb Farhane, Haq Nawaz, Franck Bonnier, Hugh Byrne Mar 2018

In Vitro Label Free Screening Of Chemotherapeutic Drugs Using Raman Micro-Spectroscopy: Towards A New Paradigm Of Spectralomics., Zeineb Farhane, Haq Nawaz, Franck Bonnier, Hugh Byrne

Articles

This overview groups some of the recent studies highlighting the potential application of Raman micro-spectroscopy as an analytical technique in preclinical development to predict drug mechanism of action and in clinical application as a companion diagnostic and in personalised therapy due to its capacity to predict cellular resistance and therefore to optimise chemotherapeutic treatment efficacy.

Notably, the anthracyclines, Doxorubicin and Actinomycin D, elicit similar spectroscopic signatures of subcellular interaction characteristic of the mode of action of intercalation. Although Cisplatin and Vincristine show markedly different signatures, at low exposure doses, their signatures at higher doses show marked similarities to those elicited ...


Antifungal Potential Of Copper(Ii), Manganese(Ii) And Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming The Candida Haemulonii Complex: Impact On The Planktonic And Biofilm Lifestyles, Rafael M. Gandra, Pauraic Mc Carron, Mariana F. Fernandes, Lívia S. Ramos, Thaís P. Mello, Ana Carolina Aor, Marta H. Branquinha, Malachy Mccann, Michael Devereux, André L. S. Santos Jul 2017

Antifungal Potential Of Copper(Ii), Manganese(Ii) And Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming The Candida Haemulonii Complex: Impact On The Planktonic And Biofilm Lifestyles, Rafael M. Gandra, Pauraic Mc Carron, Mariana F. Fernandes, Lívia S. Ramos, Thaís P. Mello, Ana Carolina Aor, Marta H. Branquinha, Malachy Mccann, Michael Devereux, André L. S. Santos

Articles

Candida haemulonii, Candida haemulonii var. vulnera and Candida duobushaemulonii, which form the C. haemulonii complex, are emerging etiologic agents of fungal infections known to be resistant to the most commonly used antifungals. The well-established anti-Candida potential ofmetal complexes containing 1,10-phenanthroline (phen) ligands encouraged us to evaluate different copper(II), manganese(II), and silver(I) phen chelates for their ability to inhibit planktonic growth and biofilm of C. haemulonii species complex. Two novel coordination complexes, {[Cu(3,6,9-tdda)(phen)2].3H2O.EtOH}n and [Ag2(3,6,9-tdda)(phen)4].EtOH (3,6,9-tddaH2 = 3,6,9-trioxaundecanedioic acid), were ...


Formulation, Characterisation And Stability Assessment Of A Food Derived 1 Tripeptide, Leucine-Lysine-Proline Loaded Chitosan Nanoparticles, M.K. Danish, Giuliana Vozza, Hugh Byrne, Jesus Frias, Sinead Ryan Jul 2017

Formulation, Characterisation And Stability Assessment Of A Food Derived 1 Tripeptide, Leucine-Lysine-Proline Loaded Chitosan Nanoparticles, M.K. Danish, Giuliana Vozza, Hugh Byrne, Jesus Frias, Sinead Ryan

Articles

The chicken or fish derived tripeptide, Leucine-Lysine-Proline (LKP), inhibits the Angiotensin Converting Enzyme and may be used as an alternative treatment for pre-hypertension. However, it has low permeation across the small intestine. The formulation of LKP into a nanoparticle (NP) has the potential to address this issue. LKP-loaded NPs were produced using an ionotropic gelation technique, using chitosan (CL113). Following optimisation of unloaded NPs, a mixture amount design was constructed using variable concentration of CL113 and tripolyphosphate at a fixed LKP concentration. Resultant particle sizes ranged from 120-271 nm, zeta potential values from 29-37 mV and polydispersity values from 0 ...


Solid-Phase Peptide Synthesis Of Analogues Of The N-Terminus A-Ring Fragment Of The Lantibiotic Nisin: Replacements For The Dehydroalanine (Dha) Residue At Position 5 And The First Incorporation Of A Thioamide Residue, Kim Manzor, Keith Ó Proinsias, Fintan Kelleher Jun 2017

Solid-Phase Peptide Synthesis Of Analogues Of The N-Terminus A-Ring Fragment Of The Lantibiotic Nisin: Replacements For The Dehydroalanine (Dha) Residue At Position 5 And The First Incorporation Of A Thioamide Residue, Kim Manzor, Keith Ó Proinsias, Fintan Kelleher

Articles

A number of A-ring analogues of the lantibiotic nisin, containing replacements for the Dha at position 5, have been successfully prepared by solid-phase peptide synthesis. The Dha replacements include glycine, alanine, phenylalanine, serine and 1-aminocyclopropyl carboxylic acid (ACCa). The incorporation of a thioamide-isoleucine residue at position 4 is also described and is the first report of the preparation of a lantibiotic ring fragment containing a thioamide link.


Conformational Studies Of Gram-Negative Bacterial Quorum Sensing 3-Oxo N-Acyl Homoserine Lactone Molecules, Darren Crowe, Alan Nicholson, Adrienne Fleming, Ed Carey, Goar Sanchez-Sanz, Fintan Kelleher Jun 2017

Conformational Studies Of Gram-Negative Bacterial Quorum Sensing 3-Oxo N-Acyl Homoserine Lactone Molecules, Darren Crowe, Alan Nicholson, Adrienne Fleming, Ed Carey, Goar Sanchez-Sanz, Fintan Kelleher

Articles

In their 1H NMR spectra in CDCl3 3-oxo-N-acyl homoserine lactones (OHLs) show significant downfield chemical shifts of the amide N-H proton when compared to the parent N-acyl homoserine lactones (AHLs). NMR spectroscopic and DFT calculation studies have shown that this is most likely due to the presence of a stabilising intramolecular H-bond from the N-H to the 3-oxo group. The 1H NMR spectra also show evidence for the enol tautomers and that the amount of enol present for a range of OHLs is 4.1-4.5% in CDCl3 and 6.5-7.2% in ...


Monitoring And Evaluation Of Terni (Central Italy) Air Quality Through Spatially Resolved Analyses, Lorenzo Massimi, Martina Ristorini, Marta Eusebio, Darla Florendo, Adeola Adeyemo, David Brugnoli, Silvia Canepari Jan 2017

Monitoring And Evaluation Of Terni (Central Italy) Air Quality Through Spatially Resolved Analyses, Lorenzo Massimi, Martina Ristorini, Marta Eusebio, Darla Florendo, Adeola Adeyemo, David Brugnoli, Silvia Canepari

Conference Papers

A study of spatial variability of PM10 elemental components was conducted in Terni city (Central Italy), situated in an intramountain depression characterized by the presence of several particulate matter emission sources. The meteorological conditions of the Terni basin limit the dispersion and enhance the accumulation of atmospheric pollutants. Thanks to the utilization of new smart samplers, used for the first time and working in parallel at 23 sampling sites, spatially resolved data were obtained. Localizations of the samplers were chosen in order to evaluate the impact of different local PM10 sources. Chemical composition of the samples was determined in combination ...


The Antibacterial Activity Of Metal Complexes Containing 1, 10-Phenanthroline: Potential As Alternatire Therapeutics In The Era Of Antibiotic Resistance, Livia Viganon, Orla L. Howe, Pauraic Mccarron, Malachy Mccann, Michael Devereux Jan 2017

The Antibacterial Activity Of Metal Complexes Containing 1, 10-Phenanthroline: Potential As Alternatire Therapeutics In The Era Of Antibiotic Resistance, Livia Viganon, Orla L. Howe, Pauraic Mccarron, Malachy Mccann, Michael Devereux

Articles

The “antibiotic era”, characterized by the overuse and misuse of antibiotics, over the last half-century has culminated in the present critical “era of resistance”. The treatment of bacterial infections is challenging because of a decline in the current arsenal of useful antibiotics and the slow rate of new drug development. The discovery of a new gene (mcr-1) in 2015, which enables bacteria to be highly resistant to polymyxins (such as colistin), the last line of antibiotic defence left, heralds a new level of concern as this gene is susceptible to horizontal gene transfer, with alarming potential to be spread between ...


Correlation Between The Structure And The Anticorrosion Barrier Properties Of Hybrid Sol–Gel Coatings: Application To The Protection Of Aa2024-T3 Alloys, Maikki Cullen, Muhammad Morshed, Mary O'Sullivan, Emma Mchugh, Brendan Duffy, Mohamed Oubaha Jan 2017

Correlation Between The Structure And The Anticorrosion Barrier Properties Of Hybrid Sol–Gel Coatings: Application To The Protection Of Aa2024-T3 Alloys, Maikki Cullen, Muhammad Morshed, Mary O'Sullivan, Emma Mchugh, Brendan Duffy, Mohamed Oubaha

Articles

Hybrid sol–gel materials have been extensively studied as viable alternatives to toxic chromate (VI)-based coatings for the corrosion protection of AA2024-T3 in the aerospace industry, due to the wide range of available chemistries they offer and the tremendous development potential of innovative functional coatings. However, so far, little work has been performed in identifying the effect of the employed chemistries on the structure and anticorrosion properties of the coatings. This work proposes to contribute to a better understanding of the relationship existing between the structure, morphology and anticorrosion properties of hybrid sol–gel coatings deposited on AA2024- T3 ...


Synthesis Of Orthogonally Protected Thioamide Dipeptides For Use In Solid-Phase Peptide Synthesis, Fintan Kelleher, Kim Manzor Nov 2016

Synthesis Of Orthogonally Protected Thioamide Dipeptides For Use In Solid-Phase Peptide Synthesis, Fintan Kelleher, Kim Manzor

Articles

Orthogonally protected thioamide-containing dipeptides were efficiently and cleanly prepared from the precursor dipeptides using Curphey’s method (P4S10, hexamethyldisiloxane (HMDO), reflux, DCM) in 67-96% isolated yield. This was in contrast to the use of Lawesson’s or Berzelius’ reagents where significant issues with reaction non-completion, decomposition and purification were observed. Subsequent clean removal of the dipeptides’ t-butyl ester protecting groups gave thioamide dipeptide acids which were suitable for use in solid-phase peptide synthesis (SPPS).


Screening The Low Molecular Weight Fraction Of Human Serum Using Atr-Ir Spectroscopy, Franck Bonnier, Matthew J. Baker, Hugh J. Byrne Jun 2016

Screening The Low Molecular Weight Fraction Of Human Serum Using Atr-Ir Spectroscopy, Franck Bonnier, Matthew J. Baker, Hugh J. Byrne

Articles

Vibrational spectroscopic techniques can detect small variations in molecular content, linked with disease, showing promise for screening and early diagnosis. Biological fluids, particularly blood serum, are potentially valuable for diagnosis purposes. The so-called Low Molecular Weight Fraction (LMWF) contains the associated peptidome and metabolome and has been identified as potentially the most relevant molecular population for disease-associated biomarker research. Although vibrational spectroscopy can deliver a specific chemical fingerprint of the samples, the High Molecular Weight Fraction (HMWF), composed of the most abundant serum proteins, strongly dominates the response and ultimately makes the detection of minor spectral variations a challenging task ...


Structural Dependence Of The In Vitro Cytotoxicity, Oxidative Stress And Uptake Mechanisms Of Poly(Propylene Imine) Dendritic Nanoparticles, Humza Khalid, Sourav Prasanna Mukherjee, Luke O'Neill, Hugh Byrne Feb 2016

Structural Dependence Of The In Vitro Cytotoxicity, Oxidative Stress And Uptake Mechanisms Of Poly(Propylene Imine) Dendritic Nanoparticles, Humza Khalid, Sourav Prasanna Mukherjee, Luke O'Neill, Hugh Byrne

Articles

The in vitro cytotoxic and intracellular oxidative stress responses to exposure to poly (propylene imine) (PPI) dendritic nanoparticles of increasing generation (number of repeated branching cycles) (G0-G4) were assessed in an immortal non-cancerous human keratinocyte cell-line (HaCaT). Confocal fluorescence microscopy with organelle staining was used to explore the uptake and intracellular trafficking mechanisms. A generation and dose dependent cytotoxic response was observed, increasing according to generation and therefore number of surface amino groups. A comparison of the cytotoxic response of G4 PPI and the related G4 Poly (amido amine) dendrimer indicates that the PPI with the same number of surface ...


Studies On The Synthesis Of Orthogonally Protected Azalanthionines, And Of Routes Towards B-Methyl Azalanthionines, By Ring-Opening Of N-Activated Aziridine-2-Crboxylates, Keith O'Brien, Keith Ó Proinsias, Fintan Kelleher Jun 2014

Studies On The Synthesis Of Orthogonally Protected Azalanthionines, And Of Routes Towards B-Methyl Azalanthionines, By Ring-Opening Of N-Activated Aziridine-2-Crboxylates, Keith O'Brien, Keith Ó Proinsias, Fintan Kelleher

Articles

Orthogonally protected azalanthionines were successfully synthesised by the ring-opening of N-activated aziridine-2-carboxylates with protected diaminopropanoic acids (DAPs). The required DAPs were also prepared by ring-opening of N-activated aziridine-2-carboxylates with para-methoxybenzylamine, but it was found that the choice of aziridine protecting groups dictated both the success of the reaction as well as the regioselectivity of the isolated products. Attempts to extend the methodology to the preparation of the more sterically demanding b-methyl azalanthionines have, so far, been unsuccessful.


Electrodeposition And Characterisation Of Copolymers Based On Pyrrole And 3,4-Ethylenedioxythiophene In Bmim Bf4 Using A Microcell Configuration, Lavinia Astratine, Edmond Magner, John Cassidy, Tony Betts Jan 2014

Electrodeposition And Characterisation Of Copolymers Based On Pyrrole And 3,4-Ethylenedioxythiophene In Bmim Bf4 Using A Microcell Configuration, Lavinia Astratine, Edmond Magner, John Cassidy, Tony Betts

Articles

Electrochemical copolymerization of pyrrole (Py) and 3,4-ethylenedioxythiophene (EDOT) was performed in an ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, (BMIM BF4) employing a ‘micro-cell’ in order to use the materials efficiently. Characterization of the copolymers formed on an ITO substrate was performed for different Py: EDOT ratios (1:2, 1:1, 2:1) in both aqueous and ionic liquid electrolytes. Electrochemical and spectroelectrochemical analysis revealed that the properties of the copolymer depend upon the Py/EDOT monomer ratio used. The copolymer PPy-co-PEDOT (2:1) displayed good stability, a switching time of 20 s and a colouration efficiency of 101.3 C-1cm2. The ...


Sol-Gel Characteristics For Corrosion Resistance Of Anodised Aluminium, Michael Whelan, John Cassidy, Brendan Duffy Jan 2013

Sol-Gel Characteristics For Corrosion Resistance Of Anodised Aluminium, Michael Whelan, John Cassidy, Brendan Duffy

Articles

Conventional anodising electrolytes based on sulphuric acid, oxalic acid and phosphoric acid have been used to form nanoporous layers on AA3003-H14 and sealed with silane based sol-gel sealers. It is shown that the sol-gel chemistries have varying levels of pore penetration depending on the synthesis conditions. The extent of sol-gel penetration and pore sealing is analysed by electron microscopy and energy dispersive x-ray spectroscopy. To describe the sealing phenomena observed a sol-gel penetration and sealing rating has been proposed to explain the interactions of the sol-gels with the pores of the anodised layers. The corrosion resistance of the sol-gel sealed ...


Systematic Synthesis And Study Of The Structure-Property Relationships Of Arylene Vinylene Polymers., Patrick Lynch Jan 2008

Systematic Synthesis And Study Of The Structure-Property Relationships Of Arylene Vinylene Polymers., Patrick Lynch

Doctoral

Much is known about the electronic, vibrational and steric effects resulting from the addition of differing organic functional groups as side chains, to the parent conjugated polymer. However the same cannot be said about the substitution of constituents of the polymer backbone itself. To this end a study is presented here which systematically studies the effects of naphthalene and anthracene substitution of the properties of poly phenylene vinylene (PPV) derivative conjugated polymers. The synthesis by the Witting-Horner reaction of derivatives is presented whereby the phenylene units of the PPV structure are methodically substituted by naphthylene and anthrylene units to form ...


Metallo-Cyclodextrin Complexes For The Separation Of Chiral Materials, Synthesis And Characterisation, Ciaran Francis Potter Jun 2007

Metallo-Cyclodextrin Complexes For The Separation Of Chiral Materials, Synthesis And Characterisation, Ciaran Francis Potter

Doctoral

The processes of separation and detection of chiral compounds are extremely important in the pharmaceutical industry. This study aims to investigate a safe and variable methods for the separation of the two enantiomers of the drug DOPA (Dihydroxyphenylalanine). L-DOPA is the most effective drug at present used to combat Parkinson’s disease while D-DOPA is inactive, thus for drug efficacy only the single biologically active enantiomer should be present in the formulation. In this work, cyclodextrins (CDS) were utilised fro their ability to act as a host for guest species, acting in the role as both a first and second ...


The Synthesis Of Zinc Oxide By Direct And Indirect Methods, Grainne Duffy Jul 2006

The Synthesis Of Zinc Oxide By Direct And Indirect Methods, Grainne Duffy

Masters

The synthesis of zinc oxide through three routes was investigated; carboxylic acid chelation, polymer assisted synthesis in an alcoholic medium and slow thermolysis of precursor. In the case of carboxylic acid chelation, it was determined that the rate at which the precursor is formed has a significant effect on the quality of zinc oxide particles produced. Investigation of the effect of concentration, pH and species of chelating agent used on the purity and structure of product was undertaken. Examination of the composition and morphology of materials produced revealed the presence of single-crystalline spheres, the packing density and aggregation morphology of ...


Increased Frequency Of The Mthfr A1298c Mutation In An Irish Population, Cathal Mccarthy, Fergus Ryan, Joseph Vaughan Jan 2004

Increased Frequency Of The Mthfr A1298c Mutation In An Irish Population, Cathal Mccarthy, Fergus Ryan, Joseph Vaughan

Articles

No abstract provided.