Open Access. Powered by Scholars. Published by Universities.®

Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

Royal College of Surgeons in Ireland

2012

Articles 1 - 1 of 1

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Targeted Antimicrobial Peptides., Marc Devocelle Jan 2012

Targeted Antimicrobial Peptides., Marc Devocelle

Chemistry Articles

The existence of natural antimicrobial substances, contributing to the mechanisms of host defenses, has been recognized since the late nineteenth century. In 1963, the in vitro antibacterial activity of leukocyte extracts was attributed to basic proteins. Since the late 1980s, cationic peptides with antimicrobial properties have been subsequently identified in other host cells and tissues and in virtually every living species (Lehrer, 2004). The properties of these “Nature’s antibiotics” and their multiple functions in host defenses of multicellular organisms support the rationale of developing entirely novel peptide-based therapeutics harnessing the effector mechanisms of innate immunity (Hancock and Sahl, 2006 ...