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Medicinal-Pharmaceutical Chemistry Commons

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Royal College of Surgeons in Ireland

Chemistry Articles

Anti-Cancer

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

A Novel Dual-Functioning Ruthenium(Ii)-Arene Complex Of An Anti-Microbial Ciprofloxacin Derivative - Anti-Proliferative And Anti-Microbial Activity., Ziga Ude, Isolda Romero-Canelón, Brendan Twamley, Deirdre Fitzgerald-Hughes, Peter J. Sadler, Celine Marmion Jan 2016

A Novel Dual-Functioning Ruthenium(Ii)-Arene Complex Of An Anti-Microbial Ciprofloxacin Derivative - Anti-Proliferative And Anti-Microbial Activity., Ziga Ude, Isolda Romero-Canelón, Brendan Twamley, Deirdre Fitzgerald-Hughes, Peter J. Sadler, Celine Marmion

Chemistry Articles

7-(4-(Decanoyl)piperazin-1-yl)-ciprofloxacin, CipA, (1) which is an analogue of the antibiotic ciprofloxacin, and its ruthenium(II) complex [Ru(η(6)-p-cymene)(CipA-H)Cl], (2) have been synthesised and the x-ray crystal structures of 1·1.3H2O·0.6CH3OH and 2·CH3OH·0.5H2O determined. The complex adopts a typical pseudo-octahedral 'piano-stool' geometry, with Ru(II) π-bonded to the p-cymene ring and σ-bonded to a chloride and two oxygen atoms of the chelated fluoroquinolone ligand. The complex is highly cytotoxic in the low μM range and is as potent as the clinical drug cisplatin against the human cancer ...


Current And Potential Applications Of Bismuth-Based Drugs., Donal M. Keogan, Darren M. Griffith Jan 2014

Current And Potential Applications Of Bismuth-Based Drugs., Donal M. Keogan, Darren M. Griffith

Chemistry Articles

Bismuth compounds have been used extensively as medicines and in particular for the treatment of gastrointestinal ailments. In addition to bismuth's well known gastroprotective effects and efficacy in treating H. pylori infection it also has broad anti-microbial, anti-leishmanial and anti-cancer properties. Aspects of the biological chemistry of bismuth are discussed and biomolecular targets associated with bismuth treatment are highlighted. This review strives to provide the reader with an up to date account of bismuth-based drugs currently used to treat patients and discuss potential medicinal applications of bismuth drugs with reference to recent developments in the literature. Ultimately this review ...