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Medicinal-Pharmaceutical Chemistry Commons

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Royal College of Surgeons in Ireland

Chemistry Articles

2018

Prodigiosin

Articles 1 - 1 of 1

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Real-Time Recording Of The Cellular Effects Of The Anion Transporter Prodigiosin., Shane Cheung, Dan Wu, Harrison C. Daly, Nathalie Busschaert, Marina Morgunova, Jeremy C. Simpson, Dimitri Scholz, Philip A. Gale, Donal F. O'Shea Apr 2018

Real-Time Recording Of The Cellular Effects Of The Anion Transporter Prodigiosin., Shane Cheung, Dan Wu, Harrison C. Daly, Nathalie Busschaert, Marina Morgunova, Jeremy C. Simpson, Dimitri Scholz, Philip A. Gale, Donal F. O'Shea

Chemistry Articles

The unraveling of the cellular effects of anion transporters is key to their potential development as apoptosis-inducing or autophagy-disrupting therapeutics. Here, we conducted a systematic study of the cellular responses to the anion transporter prodigiosin by using a pH on/off responsive near-infrared (NIR)-fluorescent probe in HeLa and LAMP1-GFP-transfected HeLa cell lines. The sequence of localized and global cellular acidity changes and the resulting outcomes induced by the anion transporter were visualized with high temporal and spatial resolution. The results show that prodigiosin causes the pH within the lysosomal lumen to rise, after which a non-organelle-specific increase in acidity ...