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Medicinal-Pharmaceutical Chemistry Commons

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Physical Chemistry

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Edward Yu

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Crystal Structure Of The Alcanivorax Borkumensis Ydah Transporter Reveals An Unusual Topology, Jani Reddy Bolla, Chih-Chia Su, Jared A. Delmar, Pattathil Radhakrishnan, Nitin Kumar, Tsung-Han Chou, Feng Long, Kanagalaghatta R. Rajashankar, Edward Yu Dec 2015

Crystal Structure Of The Alcanivorax Borkumensis Ydah Transporter Reveals An Unusual Topology, Jani Reddy Bolla, Chih-Chia Su, Jared A. Delmar, Pattathil Radhakrishnan, Nitin Kumar, Tsung-Han Chou, Feng Long, Kanagalaghatta R. Rajashankar, Edward Yu

Edward Yu

The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis encodes an integral membrane protein of the AbgT family of transporters for which no structural information was available. Here we report the crystal structure of A. borkumensis YdaH, revealing a dimeric molecule with an architecture distinct from other families of transporters. YdaH is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to ...


Acrb Multidrug Efflux Pump Of Escherichia Coli: Composite Substrate-Binding Cavity Of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity, Edward Yu, Julio R. Aires, Hiroshi Nikaido Jan 2003

Acrb Multidrug Efflux Pump Of Escherichia Coli: Composite Substrate-Binding Cavity Of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity, Edward Yu, Julio R. Aires, Hiroshi Nikaido

Edward Yu

Gram-negative bacteria have, in general, much higher intrinsic levels of resistance to various antibiotics, antiseptics, dyes, and detergents than do gram-positive bacteria. This is, in part, due to the effectiveness of the outer membrane as a barrier. The porin channels exclude large compounds (for example, vancomycin) and drastically slow down the influx of most antibiotics, which are usually much larger than common nutrients. Most antibiotics and chemotherapeutic agents that act on targets in the cytosol must cross the inner, cytoplasmic membrane, usually by spontaneous diffusion, and this necessitates their being at least moderately lipophilic. These compounds can in principle diffuse ...