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Medicinal-Pharmaceutical Chemistry Commons

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Organic Chemistry

2015

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Articles 31 - 34 of 34

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Synthesis And Anti-Proliferative Activity Of N,N’-Bis(Arylmethyl)Benzimidazolium Salts, Travis M. Williams Jan 2015

Synthesis And Anti-Proliferative Activity Of N,N’-Bis(Arylmethyl)Benzimidazolium Salts, Travis M. Williams

Williams Honors College, Honors Research Projects

A series of N,N’-bis(arylmethyl)benzimidazolium salts with hydrophilic and lipophilic substituents have been synthesized, characterized, and tested against select non-small cell cancer cell lines. Substituent variations on the imidazole ring have shown that lipophilicity and hydrophilicity can influence the imidazolium salts’ anti-proliferative activity and aqueous solubility.


Ozonolysis Of Silyl Enol Ethers: Synthesis Of 3-Silyloxy-1,2-And 3-Alkyl-3-Silyloxy-1,2-Dioxolanes, Katrina Wilson Jan 2015

Ozonolysis Of Silyl Enol Ethers: Synthesis Of 3-Silyloxy-1,2-And 3-Alkyl-3-Silyloxy-1,2-Dioxolanes, Katrina Wilson

Undergraduate Honors Theses

Silyl enol ethers are important synthetic intermediates that are used in a variety of reactions. The ozonolysis of silyl enol ethers to anomalous 1,2-dioxolane products has not yet been fully been explored. Though the synthesis of silyl enol ethers from aldehydes, ketones, and esters is relatively straightforward, the most commonly used methods still require air- or moisture-sensitive conditions and/or the use of toxic solvents. We have shown that silyl enol ethers can be easily synthesized from aldehydes and ketones under mild conditions and with a straightforward workup procedure in good to excellent yields. We ozonolyzed these silyl enol ...


Design, Synthesis, And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies, Rajasekhar Reddy Rami Reddy Jan 2015

Design, Synthesis, And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies, Rajasekhar Reddy Rami Reddy

Doctoral Dissertations

Supramolecular nanoassemblies capable of reducing non-specific interactions with biological macromolecules, such as proteins, are of great importance for various biological applications especially for targeted drug delivery therapeutics. Recently, zwitterionic materials have been shown to reduce non-specific interactions with biomolecules, owing both to their charge neutrality and their ability to form strong hydration layer around zwitterions via electrostatic interactions. This dissertation focuses on design, synthesis, thorough characterization, and applications of zwitterionic amphiphilic dendrimers and polymeric materials. Firstly, A new triazole-based zwitterionic moiety was conceived and incorporated as the hydrophilic functionality in facially amphiphilic dendrons. Self-assembly characteristics and the structural and functional ...


Stereocontrolled 1,2-Cis Glycosylation As The Driving Force Of Progress In Synthetic Carbohydrate Chemistry, Swati S. Nigudkar, Alexei V. Demchenko Dec 2014

Stereocontrolled 1,2-Cis Glycosylation As The Driving Force Of Progress In Synthetic Carbohydrate Chemistry, Swati S. Nigudkar, Alexei V. Demchenko

Alexei Demchenko

Recent developments in stereoselective 1,2-cis glycosylation that have emerged during the past decade are surveyed herein. For detailed coverage of the previous achievements in the field the reader is referred to our earlier reviews: A. V. Demchenko, Curr. Org. Chem., 2003, 7, 35–79 and Synlett, 2003, 1225–1240.