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Medicinal-Pharmaceutical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

Organic Chemistry

2012

Cannabinoids, Cannabinoid receptors, Dopamine, Benzhydryl Azetidines, Diols, Oximes, Amines

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Synthesis And Development Of Potential Cb1 Receptor Neutral Antagonists, Kimari Slaughter May 2012

Synthesis And Development Of Potential Cb1 Receptor Neutral Antagonists, Kimari Slaughter

University of New Orleans Theses and Dissertations

Cannabis and its derivatives have been used for both medicinal and recreational purposes. The study of this plant led to the discovery of over 60 cannabinoids, found exclusively in cannabis, that contribute to the behavioral effects of cannabis use, the most common is delta-9-tetrahydrocannabinol. Cannabinoid receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and physical well-being. There is evidence that CB1 receptors are important to the reinforcing effects and the development of physical dependence on opiate ...