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Medicinal-Pharmaceutical Chemistry Commons

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Medical Sciences

University of Arkansas, Fayetteville

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7li Nmr Of Normal Human Erythrocytes, Rao P. Gullapalli, Roger M. Hawk, Richard A. Komoroski Jan 1989

7li Nmr Of Normal Human Erythrocytes, Rao P. Gullapalli, Roger M. Hawk, Richard A. Komoroski

Journal of the Arkansas Academy of Science

Lithium has been known to be an effective medication for people with bipolar disorder. The mechanisms of action of lithium in the brain is not very well understood. NMR spectroscopy and imaging are effective both in determining lithium levels in tissue and brain. We have monitored lithium levels in red blood cells. We have been able to separate intra- and extracellular compartments of lithium using shift reagents, thereby obtaining T^1 's of both the compartments. Lithium uptake as a function of hematocrit was monitored weekly over a 3 week period. The time constant of 50 mM lithium uptake at ...