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Medicinal-Pharmaceutical Chemistry Commons

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Inorganic Chemistry

PhD theses

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Multi-Functional Copper(Ii) Drug Candidates As Potential Anti-Cancer Agents, Tadhg James Patrick Mc Givern Jun 2016

Multi-Functional Copper(Ii) Drug Candidates As Potential Anti-Cancer Agents, Tadhg James Patrick Mc Givern

PhD theses

The development of metal complexes as therapeutic agents remains a focal point of modern medicinal inorganic chemistry. While platinum drugs are well established therapeutic agents, recent progress has shown that some copper complexes possess enhanced cytotoxic activity and in vivo cytotoxic tolerance owing to their DNA binding and DNA scission capabilities. In parallel, the design, synthesis and evaluation of enzyme inhibitors rationally chosen for their potential in suppressing tumour cell proliferation as well as possessing selective toxicity towards tumour over normal cells is another area receiving considerable attention of late.

To date, we have successfully synthesized a library of novel ...