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Medicinal-Pharmaceutical Chemistry Commons

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun Aug 2017

A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun

Electronic Theses and Dissertations

Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of ...


Discovery Of Small Molecule Fcγriia Antagonists, Michael Thai Trung King Nov 2015

Discovery Of Small Molecule Fcγriia Antagonists, Michael Thai Trung King

PhD theses

Antibodies are Y-shaped proteins that are secreted by B-cells that makes up part of the defence mechanism in the adaptive immune system. Upon infection via invading bacteria and viruses, specific antibodies are produced to target the pathogens. An antibody pathogen complex is formed and this complex interacts with its antibody receptor to be phagocytised or opsonized and is then removed from the body. IgG is one of five classes of antibodies and is the most abundant antibody found in circulation that represents over 75% of serum antibodies in the body. The IgG antibody complex can interact with cells expressing its ...


Design, Synthesis And Biological Evaluation Of Novel Compounds With Cns-Activity Targeting Cannabinoid And Biogenic Amine Receptors, Alexander M. Sherwood May 2014

Design, Synthesis And Biological Evaluation Of Novel Compounds With Cns-Activity Targeting Cannabinoid And Biogenic Amine Receptors, Alexander M. Sherwood

University of New Orleans Theses and Dissertations

This work seeks to contribute to the discipline of neuropharmacology by way of structure activity relationship from the standpoint of an organic chemist. More specifically, we sought to develop robust synthetic methodology able to efficiently produce an array of compounds for the purpose of systematic evaluation of their interaction with specific sights within the central nervous system (CNS) in order to better understand the mind and to develop drugs that may have beneficial effects on neurological function.

The focus of these studies has been toward the development of novel molecules, using a structure-activity relationship approach, that exhibit binding affinity at ...