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Medicinal-Pharmaceutical Chemistry Commons

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Cell and Developmental Biology

Antipain

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Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Echinacea In Infection1–4, Diane F. Birt, Mark P. Widrlechner, Carlie A. Lalone, Lankun Wu, Jaehoon Bae, Avery K S Solco, George A. Kraus, Patricia A. Murphy, Eve S. Wurtele, Qiang Leng, Steven C. Hebert, Wendy J. Maury, Jason P. Price Feb 2008

Echinacea In Infection1–4, Diane F. Birt, Mark P. Widrlechner, Carlie A. Lalone, Lankun Wu, Jaehoon Bae, Avery K S Solco, George A. Kraus, Patricia A. Murphy, Eve S. Wurtele, Qiang Leng, Steven C. Hebert, Wendy J. Maury, Jason P. Price

Genetics, Development and Cell Biology Publications

Ongoing studies have developed strategies for identifying key bioactive compounds and chemical profiles in Echinacea with the goal of improving its human health benefits. Antiviral and antiinflammatory–antipain assays have targeted various classes of chemicals responsible for these activities. Analysis of polar fractions of E. purpurea extracts showed the presence of antiviral activity, with evidence suggesting that polyphenolic compounds other than the known HIV inhibitor, cichoric acid, may be involved. Antiinflammatory activity differed by species, with E. sanguinea having the greatest activity and E. angustifolia, E. pallida, and E. simulata having somewhat less. Fractionation and studies with pure compounds indicate ...