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Full-Text Articles in Medicinal-Pharmaceutical Chemistry
Structure-Based Design Of Inhibitors Targeting Influenza A Virus M2 Proton Channel (A/M2), Jun Wang
Publicly Accessible Penn Dissertations
Influenza A virus M2 (A/M2) forms a homotetrameric channel in viral membranes that is highly selective for protons. A/M2 has been extensively studied by electrophysiologists, biophysicists, structural biologists and biochemists in order to understand the mechanism and selectivity of proton conductance from the structural basis. Medicinal chemists have also studied A/M2 as therapeutic target for anti-flu drugs. However, research on A/M2 drug binding lead to entirely different binding sites of two very similar anti-flu drugs. In light of the urgency in developing novel antivirals against drug resistant A/M2 mutants, it is imperative to solve this ...