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Biochemistry

Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)

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Characterization Of Gold Nanoparticle Antimicrobials, Kelsey Higgins Jan 2014

Characterization Of Gold Nanoparticle Antimicrobials, Kelsey Higgins

Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)

Nanoparticles have been gaining recognition for their potential in drug delivery; however, now a new niche is growing. Nanoparticles are no longer simply carrying a drug, but rather being designed as the therapeutic itself. The Feldheim group has designed gold nanoparticles functionalized with an array of organothiol ligands varying in intermolecular forces, hydrophilicity and functional groups. Optimization of this library of drug nanoparticles produced drug nanoparticles with a bacteriostatic effect against bacteria, such as E. Coli and Klebsiella. There are still many pieces of the puzzle to address. This thesis presents research conducted to 1) Explore which parameter during the ...