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Medicinal-Pharmaceutical Chemistry Commons

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Articles 1 - 4 of 4

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, L. Chen, Xia Zhao, Y. Lin, Y. Huang, Qian Wang Jan 2013

A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, L. Chen, Xia Zhao, Y. Lin, Y. Huang, Qian Wang

Faculty Publications

Using a one-pot approach driven by the supramolecular interaction between β-cyclodextrin and adamantyl moieties, multifunctional viral nanoparticles can be facilely formulated for biomedical applications.


Breast Tumour Initiating Cell Fate Is Regulated By Microenvironmental Cues From An Extracellular Matrix, S. Saha, Pang-Kuo Lo, X. Duan, Hexin Chen, Qian Wang Jan 2012

Breast Tumour Initiating Cell Fate Is Regulated By Microenvironmental Cues From An Extracellular Matrix, S. Saha, Pang-Kuo Lo, X. Duan, Hexin Chen, Qian Wang

Faculty Publications

Cancer stem cells, also known as tumour-initiating cells (TICs), are identified as highly tumorigenic population within tumours and hypothesized to be main regulators in tumour growth, metastasis and relapse. Evidence also suggests that a tumour microenvironment plays a critical role in the development and progression of cancer, by constantly modulating cell–matrix interactions. Scientists have tried to characterize and identify the TIC population but the actual combination of extracellular components in deciphering the fate of TICs has not been explored. The basic unanswered question is the phenotypic stability of this TIC population in a tissue extracellular matrix setting. The in ...


Discrimination Of Colon Cancer Stem Cells Using Noncanonical Amino Acid, X. Duan, H. Li, Hexin Chen, Qian Wang Jan 2012

Discrimination Of Colon Cancer Stem Cells Using Noncanonical Amino Acid, X. Duan, H. Li, Hexin Chen, Qian Wang

Faculty Publications

Cancer stem cells (CSCs) may be responsible for tumor recurrence. Metabolic labelling of newly synthesized proteins with non-canonical amino acids allows us to discriminate CSCs in mixed populations due to the quiescent nature of these cells.


Oriented Cell Growth On Self-Assembled Bacteriophage M13 Thin Films, J. Rong, L. A. Lee, K. Li, B. Harp, C. M. Mello, Z. Niu, Qian Wang Jan 2008

Oriented Cell Growth On Self-Assembled Bacteriophage M13 Thin Films, J. Rong, L. A. Lee, K. Li, B. Harp, C. M. Mello, Z. Niu, Qian Wang

Faculty Publications

Fibrillar M13 bacteriophages were used as basic building blocks to generate thin films with aligned nanogrooves, which, upon chemical grafting with RGD peptides, guide cell alignment and orient the cell outgrowth along defined directions.