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Full-Text Articles in Pharmaceutics and Drug Design

The [E]Motionless Body No Longer: Tracing The Historical Intersections Of Mental Illness And Movement In The American Asylum, Holly Adele Herzfeld Jan 2017

The [E]Motionless Body No Longer: Tracing The Historical Intersections Of Mental Illness And Movement In The American Asylum, Holly Adele Herzfeld

Senior Projects Spring 2017

Senior Project submitted to The Division of Multidisciplinary Studies of Bard College.


Preparation Of Gold Nanoparticle-Cisplatin Conjugates And Investigation Of Their Toxicity In Zebrafish, Jasper Zee Williams Jan 2014

Preparation Of Gold Nanoparticle-Cisplatin Conjugates And Investigation Of Their Toxicity In Zebrafish, Jasper Zee Williams

Senior Projects Spring 2014

The chemotherapy drug cisplatin is used to treat a wide variety of cancers; however, it has a number of side effects, such as damage to hearing or balance functions of the ear defined as ototoxicity, that can limit its use. The goal of this study was to use larval zebrafish as an in vivo model to investigate whether conjugation to gold nanoparticles (AuNPs) reduces cisplatin’s ototoxicity. AuNPs-cisplatin conjugates were synthesized using a seeded-growth approach, and the loading of cisplatin on the nanoparticles was measured by inductively coupled plasma optical emission spectroscopy (ICP-OES). The conjugates synthesized were found to contain ...