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Full-Text Articles in Cell Biology
Transgneic Endothelin 3 Regulates Murine Pigment Production And Coat Color, Javier Pino
FIU Electronic Theses and Dissertations
Pigmentation plays a protective role against damage caused by ultraviolet (UV) irradiation. Humans with fair skin and light hair have a higher susceptibility to UV-induced DNA damage that can lead to the development of skin cancers. The melanocytes found in the skin and hair follicles depend on different signaling molecules for their proper development and pigment production. α-Melanocyte Stimulating Hormone (α-msh) binds to the Melanocortin 1 receptor (Mc1r) to regulate pigment production and the switch between eumelanin and pheomelanin. Lethal yellow mice (Ay) overexpress the agouti signaling protein, which inhibits the binding of α-msh, resulting in a yellow coat ...
The Effect Of Exercise On Endothelin And Endothelin Receptor Levels In Shr And Wky Male And Female Rats, Lacey Stiller
All Theses, Dissertations, and Other Capstone Projects
The role of exercise as a means to modulate renal function in hypertension is unclear. However, prior studies in the laboratory of Dr. Penny Knoblich indicate that exercised female spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats excrete significantly more sodium in response to a rise in blood pressure relative to exercised male and sedentary female SHR and WKY rats. The purpose of this study was to evaluate the effects of exercise on endothelin and endothelin receptor levels in the urine and kidneys of male and female SHR and WKY rats, to elucidate potential mechanisms to explain an increase ...