Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Cytoskeleton

Immunology and Infectious Disease

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

Lytic Granule Convergence To The Microtubule Organizing Center In Natural Killer Cells, Ashley Mentlik James Jan 2012

Lytic Granule Convergence To The Microtubule Organizing Center In Natural Killer Cells, Ashley Mentlik James

Publicly Accessible Penn Dissertations

Natural killer (NK) cells are lymphocytes of the innate immune system that participate in host defense by secreting the contents of specialized secretory organelles termed lytic granules onto virally infected or tumorigenic cells in order to terminate them. Lysis of these target cells is a highly regulated, stepwise process beginning with actin rearrangement into an immunological synapse (IS) at the contact site between NK cell and target cell, followed by microtubule organizing center (MTOC) polarization towards the target cell, and culminating in the release of lytic granule contents through the actin network at the IS. The NK cell is capable ...