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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2014

Actin

Theses and Dissertations

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Full-Text Articles in Cell Biology

Prostaglandin Signaling Temporally Regulates Actin Cytoskeletal Remodeling During Drosophila Oogenesis, Andrew James Spracklen Jul 2014

Prostaglandin Signaling Temporally Regulates Actin Cytoskeletal Remodeling During Drosophila Oogenesis, Andrew James Spracklen

Theses and Dissertations

Prostaglandins (PGs) are small, lipid signaling molecules produced downstream of cyclooxygenase (COX) enzymes. PG signaling regulates many processes including pain, inflammation, fertility, cardiovascular function and disease, and cancer. One mechanism by which PG signaling exerts its function is by regulating the dynamics of the actin cytoskeleton; however, the exact mechanisms remain largely undefined.

Drosophila oogenesis provides an ideal system to determine how PG signaling regulates the actin cytoskeleton. Drosophila follicles, or eggs, pass through 14 well- characterized, morphologically defined stages of development. Each developing follicle is comprised of 16 interconnected germline-derived cells (15 nurse cells and 1 oocyte) that are ...