Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 3 of 3

Full-Text Articles in Cell Biology

Cooperative Binding Of The Outer Arm-Docking Complex Underlies The Regular Arrangement Of Outer Arm Dynein In The Axoneme, Mikito Owa, Akane Furuta, Jiro Usukura, Fumio Arisaka, Stephen M. King, George B. Witman, Ritsu Kamiya, Ken-Ichi Wakabayashi Jul 2014

Cooperative Binding Of The Outer Arm-Docking Complex Underlies The Regular Arrangement Of Outer Arm Dynein In The Axoneme, Mikito Owa, Akane Furuta, Jiro Usukura, Fumio Arisaka, Stephen M. King, George B. Witman, Ritsu Kamiya, Ken-Ichi Wakabayashi

Cell and Developmental Biology Publications

Outer arm dynein (OAD) in cilia and flagella is bound to the outer doublet microtubules every 24 nm. Periodic binding of OADs at specific sites is important for efficient cilia/flagella beating; however, the molecular mechanism that specifies OAD arrangement remains elusive. Studies using the green alga Chlamydomonas reinhardtii have shown that the OAD-docking complex (ODA-DC), a heterotrimeric complex present at the OAD base, functions as the OAD docking site on the doublet. We find that the ODA-DC has an ellipsoidal shape approximately 24 nm in length. In mutant axonemes that lack OAD but retain the ODA-DC, ODA-DC molecules are ...


Hdac4 Integrates Pth And Sympathetic Signaling In Osteoblasts, Arnaud Obri, Munevver Parla. Makinistoglu, Hong Zhang, Gerard Karsenty Jun 2014

Hdac4 Integrates Pth And Sympathetic Signaling In Osteoblasts, Arnaud Obri, Munevver Parla. Makinistoglu, Hong Zhang, Gerard Karsenty

Cell and Developmental Biology Publications

Parathyroid hormone (PTH) and the sympathetic tone promote Rankl expression in osteoblasts and osteoclast differentiation by enhancing cyclic adenosine monophosphate production through an unidentified transcription factor for PTH and through ATF4 for the sympathetic tone. How two extracellular cues using the same second messenger in the same cell elicit different transcriptional events is unknown. In this paper, we show that PTH favors Rankl expression by triggering the ubiquitination of HDAC4, a class II histone deacetylase, via Smurf2. HDAC4 degradation releases MEF2c, which transactivates the Rankl promoter. Conversely, sympathetic signaling in osteoblasts favors the accumulation of HDAC4 in the nucleus and ...


Uniform Nomenclature For The Mitochondrial Contact Site And Cristae Organizing System, Nikolaus Pfanner, Paul R. Odgren Phd, Walter Neupert, Jodi Nunnari Mar 2014

Uniform Nomenclature For The Mitochondrial Contact Site And Cristae Organizing System, Nikolaus Pfanner, Paul R. Odgren Phd, Walter Neupert, Jodi Nunnari

Cell and Developmental Biology Publications

The mitochondrial inner membrane contains a large protein complex that functions in inner membrane organization and formation of membrane contact sites. The complex was variably named the mitochondrial contact site complex, mitochondrial inner membrane organizing system, mitochondrial organizing structure, or Mitofilin/Fcj1 complex. To facilitate future studies, we propose to unify the nomenclature and term the complex "mitochondrial contact site and cristae organizing system" and its subunits Mic10 to Mic60.