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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Grand Valley State University

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

A Chemical Genetics Approach To Elucidate Mechanisms Of The Fission Yeast Polo Kinase In Cell Division, Jennifer Phelan, Dawn Clifford Hart Jan 2010

A Chemical Genetics Approach To Elucidate Mechanisms Of The Fission Yeast Polo Kinase In Cell Division, Jennifer Phelan, Dawn Clifford Hart

Student Summer Scholars Manuscripts

Cell division is a fundamental biological event that underlies the growth and development of all organisms. Because human and fission yeast (Schizosaccharomyces pombe) cells divide symmetrically through constriction of the actomyosin ring, fission yeast provides an ideal model system to reveal conserved cell cycle properties. In fission yeast, an evolutionarily conserved protein, Mid1, plays a critical role in organizing the early steps of contractile ring formation. Mid1 functions as a scaffold to bridge the cell cortex with the contractile ring. Cells lacking mid1 form off-centered, highly disorganized ring structures and exhibit severe cell division defects. Our previous research demonstrates that ...