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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Chemicals and Drugs

Migration

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Full-Text Articles in Cell Biology

Cip4 And Src In Promoting The Migration And Invasion Of Breast Cancers, Christina S. Pichot May 2010

Cip4 And Src In Promoting The Migration And Invasion Of Breast Cancers, Christina S. Pichot

UT GSBS Dissertations and Theses (Open Access)

Cellular invasion represents a critical early step in the metastatic cascade, and many proteins have been identified as part of an “invasive signature.” The non-receptor tyrosine kinase Src is commonly upregulated in breast cancers, often in conjunction with overexpression of EGFR. Signaling from this pathway stimulates cell proliferation, migration, and invasion and frequently involves proteins that regulate the cytoskeleton. My data demonstrates that inhibition of Src, using the small-molecule inhibitor dasatinib, impairs cellular migration and invasion. Furthermore, Src inhibition sensitizes the cells to the effects of the chemotherapeutic doxorubicin resulting in dramatic, synergistic inhibition of proliferation with combination treatments. The ...