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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Biochemistry

Amino Acid Sequence; Amnesia; Animals; Anisomycin; Association Learning; Avoidance Learning; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Down-Regulation; Female; Hippocampus; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 10; inhibitors; Mitogen-Activated Protein Kinase 8; inhibitors; Mitogen-Activated Protein Kinase 9; inhibitors; Molecular Sequence Data; Neurons; Protein Kinase Inhibitors; Stress, Psychological

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Full-Text Articles in Cell Biology

Hippocampal C-Jun-N-Terminal Kinases Serve As Negative Regulators Of Associative Learning, Tessi Sherrin, Thomas Blank, Cathrin Hippel, Martin Rayner, Roger J. Davis, Cedomir Todorovic Oct 2010

Hippocampal C-Jun-N-Terminal Kinases Serve As Negative Regulators Of Associative Learning, Tessi Sherrin, Thomas Blank, Cathrin Hippel, Martin Rayner, Roger J. Davis, Cedomir Todorovic

Davis Lab Publications

In the adult mouse, signaling through c-Jun N-terminal kinases (JNKs) links exposure to acute stress to various physiological responses. Inflammatory cytokines, brain injury and ischemic insult, or exposure to psychological acute stressors induce activation of hippocampal JNKs. Here we report that exposure to acute stress caused activation of JNKs in the hippocampal CA1 and CA3 subfields, and impaired contextual fear conditioning. Conversely, intrahippocampal injection of JNKs inhibitors sp600125 (30 mum) or D-JNKI1 (8 mum) reduced activity of hippocampal JNKs and rescued stress-induced deficits in contextual fear. In addition, intrahippocampal administration of anisomycin (100 mug/mul), a potent JNKs activator, mimicked ...