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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Biochemistry

Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cells, Cultured; Female; Ganglia, Spinal; Genotype; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Nerve Regeneration; Neurites; Phosphorylation; Polymerase Chain Reaction; Signal Transduction

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

Distinct Roles Of C-Jun N-Terminal Kinase Isoforms In Neurite Initiation And Elongation During Axonal Regeneration, Monia Barnat, Herve Enslen, Friedrich Propst, Roger J. Davis, Sylvia Soares, Fatiha Nothias Jun 2010

Distinct Roles Of C-Jun N-Terminal Kinase Isoforms In Neurite Initiation And Elongation During Axonal Regeneration, Monia Barnat, Herve Enslen, Friedrich Propst, Roger J. Davis, Sylvia Soares, Fatiha Nothias

Davis Lab Publications

c-Jun N-terminal kinases (JNKs) (comprising JNK1-3 isoforms) are members of the MAPK (mitogen-activated protein kinase) family, activated in response to various stimuli including growth factors and inflammatory cytokines. Their activation is facilitated by scaffold proteins, notably JNK-interacting protein-1 (JIP1). Originally considered to be mediators of neuronal degeneration in response to stress and injury, recent studies support a role of JNKs in early stages of neurite outgrowth, including adult axonal regeneration. However, the function of individual JNK isoforms, and their potential effector molecules, remained unknown. Here, we analyzed the role of JNK signaling during axonal regeneration from adult mouse dorsal root ...