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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Biochemistry

Adaptor Proteins, Signal Transducing; Adipokines; Animals; Blood Glucose; Cytokines; Dietary Fats; Energy Metabolism; Enzyme Activation; Fatty Liver; Female; Immunoblotting; Insulin; *Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

Requirement Of Jip1-Mediated C-Jun N-Terminal Kinase Activation For Obesity-Induced Insulin Resistance, Caroline Morel, Claire L. Standen, Dae Young Jung, Susan Gray, Helena Ong, Richard A. Flavell, Jason K. Kim, Roger J. Davis Oct 2010

Requirement Of Jip1-Mediated C-Jun N-Terminal Kinase Activation For Obesity-Induced Insulin Resistance, Caroline Morel, Claire L. Standen, Dae Young Jung, Susan Gray, Helena Ong, Richard A. Flavell, Jason K. Kim, Roger J. Davis

Davis Lab Publications

The c-Jun NH(2)-terminal kinase (JNK) interacting protein 1 (JIP1) has been proposed to act as a scaffold protein that mediates JNK activation. However, recent studies have implicated JIP1 in multiple biochemical processes. Physiological roles of JIP1 that are related to the JNK scaffold function of JIP1 are therefore unclear. To test the role of JIP1 in JNK activation, we created mice with a germ line point mutation in the Jip1 gene (Thr(103) replaced with Ala) that selectively blocks JIP1-mediated JNK activation. These mutant mice exhibit a severe defect in JNK activation caused by feeding of a high-fat ...