Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 2 of 2

Full-Text Articles in Cell Biology

Stromal Cell-Derived Factor-1 (Chemokine C-X-C Motif Ligand 12) And Chemokine C-X-C Motif Receptor 4 Are Required For Migration Of Gonadotropin-Releasing Hormone Neurons To The Forebrain, Gerald A. Schwarting, Timothy R. Henion, J. David Nugent, Benjamin Caplan, Stuart A. Tobet Jun 2006

Stromal Cell-Derived Factor-1 (Chemokine C-X-C Motif Ligand 12) And Chemokine C-X-C Motif Receptor 4 Are Required For Migration Of Gonadotropin-Releasing Hormone Neurons To The Forebrain, Gerald A. Schwarting, Timothy R. Henion, J. David Nugent, Benjamin Caplan, Stuart A. Tobet

Schwarting Lab Publications

Gonadotropin-releasing hormone (GnRH) neurons migrate from the vomeronasal organ (VNO) in the nasal compartment to the basal forebrain in mice, beginning on embryonic day 11 (E11). These neurons use vomeronasal axons as guides to migrate through the nasal mesenchyme. Most GnRH neurons then migrate along the caudal branch of the vomeronasal nerve to reach the hypothalamus. We show here that stromal cell-derived factor-1 [SDF-1, also known as chemokine C-X-C motif ligand 12 (CXCL12)] is expressed in the embryonic nasal mesenchyme from as early as E10 in an increasing rostral to caudal gradient that is most intense at the border of ...


Minireview: Recent Progress In Gonadotropin-Releasing Hormone Neuronal Migration, Stuart A. Tobet, Gerald A. Schwarting Mar 2006

Minireview: Recent Progress In Gonadotropin-Releasing Hormone Neuronal Migration, Stuart A. Tobet, Gerald A. Schwarting

Schwarting Lab Publications

Neurons that synthesize GnRH are critical brain regulators of the reproductive axis, yet they originate outside the brain and must migrate over long distances and varied environments to get to their appropriate positions during development. Many studies, past and present, are providing clues for the types of molecules encountered and movements expected along the migratory route. Recent studies provide real-time views of the behavior of GnRH neurons in the context of in vitro preparations that model those in vivo. Live images provide direct evidence of the changing behavior of GnRH neurons in their different environments, showing that GnRH neurons move ...