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Cell Biology Commons

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2006

McCabe Thesis Collection

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Full-Text Articles in Cell Biology

Exogenous Expression Of Human Na, K-Atpase Isoforms In Insect Cells, Christal Renee' Carpenter Apr 2006

Exogenous Expression Of Human Na, K-Atpase Isoforms In Insect Cells, Christal Renee' Carpenter

McCabe Thesis Collection

The Na-K-ATPase or Na pump is a membrane bound enzyme that maintains a high concentration of K+ and low concentration of Na+ in most animal cells. Three subunits constitute the Na pump, named alpha (ex), beta (~). and gamma (y). The ex subunit is responsible for the catalytic and transport of the enzyme, the ~ subunit is important for bringing the ex to the plasma membrane of the cell, and y is a regulatory subunit of the Na pump. In addition, there are several molecular variants or isoforms of the ex and ~ subunits. At present four different ex (ex 1, ex2, ex3 ...