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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2006

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Animals; Cell Death; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Embryo, Mammalian; Gene Expression Regulation, Developmental; Gonadotropin-Releasing Hormone; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Mice; Mice, Knockout; Neurons; Prosencephalon; Receptors, CXCR4; Tubulin; Vomeronasal Organ

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

Stromal Cell-Derived Factor-1 (Chemokine C-X-C Motif Ligand 12) And Chemokine C-X-C Motif Receptor 4 Are Required For Migration Of Gonadotropin-Releasing Hormone Neurons To The Forebrain, Gerald A. Schwarting, Timothy R. Henion, J. David Nugent, Benjamin Caplan, Stuart A. Tobet Jun 2006

Stromal Cell-Derived Factor-1 (Chemokine C-X-C Motif Ligand 12) And Chemokine C-X-C Motif Receptor 4 Are Required For Migration Of Gonadotropin-Releasing Hormone Neurons To The Forebrain, Gerald A. Schwarting, Timothy R. Henion, J. David Nugent, Benjamin Caplan, Stuart A. Tobet

Schwarting Lab Publications

Gonadotropin-releasing hormone (GnRH) neurons migrate from the vomeronasal organ (VNO) in the nasal compartment to the basal forebrain in mice, beginning on embryonic day 11 (E11). These neurons use vomeronasal axons as guides to migrate through the nasal mesenchyme. Most GnRH neurons then migrate along the caudal branch of the vomeronasal nerve to reach the hypothalamus. We show here that stromal cell-derived factor-1 [SDF-1, also known as chemokine C-X-C motif ligand 12 (CXCL12)] is expressed in the embryonic nasal mesenchyme from as early as E10 in an increasing rostral to caudal gradient that is most intense at the border of ...