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Cell Biology Commons

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2006

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And molecular biology

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Full-Text Articles in Cell Biology

From Endomembrane To The Plasma Membrane: The Traffic, Signal Transduction And Micro-Localization Of H-Ras , Hui Zheng Jan 2006

From Endomembrane To The Plasma Membrane: The Traffic, Signal Transduction And Micro-Localization Of H-Ras , Hui Zheng

Retrospective Theses and Dissertations

Ras proteins are small G proteins that play key roles in many aspect of cell signal transduction. H-Ras is one of three isoforms of mammalian Ras protein that is best studied. The work presented in this dissertation describes how the carboxyl terminal lipid modifications affect the transportation, signal transduction and micro-localizations of H-Ras protein. The already known traffic pathway for H-Ras to the plasma membrane is Golgi mediated classical vesicular Transportation; However, we found the H-Ras transportation has many different features other than the classical pathway, and thereby discovered a new pathway for H-Ras targeting to the plasma membrane. This ...