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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2006

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Neuroscience and Neurobiology

Articles 1 - 2 of 2

Full-Text Articles in Cell Biology

Directed Growth And Selective Differentiation Of Neural Progenitor Cells Using A Synergistic Combination Of Topographical And Soluble Cues , Jennifer Behr Recknor Jan 2006

Directed Growth And Selective Differentiation Of Neural Progenitor Cells Using A Synergistic Combination Of Topographical And Soluble Cues , Jennifer Behr Recknor

Retrospective Theses and Dissertations

The purpose of this study is to develop strategies to facilitate nerve regeneration using a synergistic combination of guidance cues. We are investigating the cellular mechanisms of development using adult rat hippocampal progenitor cells (AHPCs) and have demonstrated that manipulating a combination of physical, chemical and biological cues can lead to oriented astrocyte and neural progenitor cell outgrowth and can influence progenitor cell differentiation. To provide physical guidance, micropatterned polystyrene (PS) substrates were fabricated and chemically modified with laminin. Astrocytes or AHPCs cultured on these substrates align along the grooves of the patterned surface extending highly elongated processes. To further ...


Comparative Study Of Immunocytochemical Patterns Of Somatotrophs, Mammotrophs, And Mammosomatotrophs In The Porcine Anterior Pituitary , Jin-Sook Lee Jan 2006

Comparative Study Of Immunocytochemical Patterns Of Somatotrophs, Mammotrophs, And Mammosomatotrophs In The Porcine Anterior Pituitary , Jin-Sook Lee

Retrospective Theses and Dissertations

The anterior pituitary gland is a dynamic and complex endocrine gland that synthesizes and secretes trophic hormones from distinct endocrine cells including mammotrophs (prolactin cells or lactotrophs) and somatotrophs (growth hormone cells) to play essential roles in the maintenance of homeostasis, metabolism, reproduction, growth, and lactation. Recently, the existence of a novel anterior pituitary cell type, the mammosomatotroph which contained both growth hormone (GH) and prolactin (PRL) was proposed to function as a transitional cell or progenitor cell between somatotrophs and mammotrophs under various physiological conditions. The present study investigated the spatial distribution patterns of somatotrophs, mammotrophs, and mammosomatotrophs by ...