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Full-Text Articles in Cell Biology

Porcine Reproductive And Respiratory Syndrome Virus Infection Of Cells: Characterization Of The Early Stages Of Virus Infection And The Major Structural Proteins Of The Virus , Luiz Carlos Kreutz Jan 1996

Porcine Reproductive And Respiratory Syndrome Virus Infection Of Cells: Characterization Of The Early Stages Of Virus Infection And The Major Structural Proteins Of The Virus , Luiz Carlos Kreutz

Retrospective Theses and Dissertations

Porcine reproductive and respiratory syndrome (PRRS) is one of the major causes of economic losses to swine producers. The causative agent, the PRRS virus (PRRSV), has been tentatively classified as an arterivirus. PRRSV infect swine alveolar macrophages and induce persistent infection. In vitro, PRRSV replication is restricted to few continuous cell lines, none of which of porcine origin. The interaction of PRRSV with cells and the major structural proteins of the virus have been investigated in these studies, aiming to better understand the mechanisms governing cell tropism and replication in cells;Several cells were used to determine the mechanism of ...


Cloning Of Bovine Intercellular Adhesion Molecules And Characterization Of Expression Of Neutrophil Adhesion Molecules In Periparturient Cows And Calves , Eunkyung Lee Jan 1996

Cloning Of Bovine Intercellular Adhesion Molecules And Characterization Of Expression Of Neutrophil Adhesion Molecules In Periparturient Cows And Calves , Eunkyung Lee

Retrospective Theses and Dissertations

The interactions of circulating leukocytes with the endothelium represent a key point in the effector functions of the immune system by regulating the specificity and strength of cell-cell interactions. The recruitment of neutrophils to sites of inflammation is initiated by chemoattractants. The initial contact of neutrophils on vascular endothelial cells is a rolling interaction mediated by members of the selectin family. These include E-selectin and P-selectin on the surface of activated endothelial cells, and L-selectin on neutrophils. The subsequent activation of leukocyte [beta]2 integrins, which bind to the glycoprotein intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, is essential for ...