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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

1996

Animals; Bufo marinus; Chickens; Fourier Analysis; Guinea Pigs; Image Processing, Computer-Assisted; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Myosins; Osmolar Concentration; Rabbits

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Full-Text Articles in Cell Biology

Myosin Filament Structure In Vertebrate Smooth Muscle, Jun-Qing Xu, Beatrice A. Harder, Pedro Uman, Roger W. Craig Jul 1996

Myosin Filament Structure In Vertebrate Smooth Muscle, Jun-Qing Xu, Beatrice A. Harder, Pedro Uman, Roger W. Craig

Open Access Articles

The in vivo structure of the myosin filaments in vertebrate smooth muscle is unknown. Evidence from purified smooth muscle myosin and from some studies of intact smooth muscle suggests that they may have a nonhelical, side-polar arrangement of crossbridges. However, the bipolar, helical structure characteristic of myosin filaments in striated muscle has not been disproved for smooth muscle. We have used EM to investigate this question in a functionally diverse group of smooth muscles (from the vascular, gastrointestinal, reproductive, and visual systems) from mammalian, amphibian, and avian species. Intact muscle under physiological conditions, rapidly frozen and then freeze substituted, shows ...