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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

1996

GSBS Student Publications

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Full-Text Articles in Cell Biology

Xist Rna Paints The Inactive X Chromosome At Interphase: Evidence For A Novel Rna Involved In Nuclear/Chromosome Structure, Christine Moulton Clemson, John A. Mcneil, Huntington F. Willard, Jeanne B. Lawrence Feb 1996

Xist Rna Paints The Inactive X Chromosome At Interphase: Evidence For A Novel Rna Involved In Nuclear/Chromosome Structure, Christine Moulton Clemson, John A. Mcneil, Huntington F. Willard, Jeanne B. Lawrence

GSBS Student Publications

The XIST gene is implicated in X chromosome inactivation, yet the RNA contains no apparent open reading frame. An accumulation of XIST RNA is observed near its site of transcription, the inactive X chromosome (Xi). A series of molecular cytogenetic studies comparing properties of XIST RNA to other protein coding RNAs, support a critical distinction for XIST RNA; XIST does not concentrate at Xi simply because it is transcribed and processed there. Most notably, morphometric and 3-D analysis reveals that XIST RNA and Xi are coincident in 2- and 3-D space; hence, the XIST RNA essentially paints Xi. Several results ...