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Full-Text Articles in Cell Biology

Reversal Of Cell Fate Determination In Caenorhabditis Elegans Vulval Development, Susan Euling, Victor Ambros Apr 1996

Reversal Of Cell Fate Determination In Caenorhabditis Elegans Vulval Development, Susan Euling, Victor Ambros

Open Dartmouth: Faculty Open Access Scholarship

In Caenorhabditis elegans, the fates of the multipotent vulval precursor cells (VPCs) are specified by intercellular signals, The VPCs divide in the third larval stage (L3) of the wild type, producing progeny of determined cell types, In lin-28 mutants, vulva development is similar to wild-type vulva development except that it occurs precociously, in the second larval stage (L2), Consequently, when lin-28 hermaphrodites temporarily arrest development at the end of L2 in the dauer larva stage, these otherwise determined VPC progeny become reprogrammed back to the multipotent, signal- sensitive state of VPCs. Our results indicate that VPC fate determination by intercellular ...


Review: To Bud Until Death: The Genetics Of Aging In The Yeast, Saccharomyces, Father Nicanor Austriaco Dec 1995

Review: To Bud Until Death: The Genetics Of Aging In The Yeast, Saccharomyces, Father Nicanor Austriaco

Rev. Nicanor Austriaco, O.P.

Individual cells of the budding yeast, Saccharomyces cerevisiae, have a limited division capacity and undergo characteristicchanges as they senesce, primarily increasing both their cell size and cell cycle time. The mortality curve for ageing yeast cells can be described by the Gompertz equation, the classical definition for an ageing population. Recent work from several laboratories has demonstrated that genes can determine the yeast lifespan. Studies with the UTH genes have implicated changes in transcriptional silencing during yeast ageing, but the roles of the RAS2, LAG1 and PHBl genes in regulating yeast longevity are still unclear. What is becoming clearer, however ...