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1991

Neuroscience and Neurobiology

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Full-Text Articles in Cell Biology

A Highly Polymorphic Dinucleotide Repeat On The Proximal Short Arm Of The Human X Chromosome: Linkage Mapping Of The Synapsin I/A-Raf-1 Genes, Cordula U. Kirchgessner, James A. Trofatter, Melanie M. Mahtani, Huntington F. Willard, Louis J. Degennaro Jul 1991

A Highly Polymorphic Dinucleotide Repeat On The Proximal Short Arm Of The Human X Chromosome: Linkage Mapping Of The Synapsin I/A-Raf-1 Genes, Cordula U. Kirchgessner, James A. Trofatter, Melanie M. Mahtani, Huntington F. Willard, Louis J. Degennaro

Open Access Articles

A compound (AC)n repeat located 1,000 bp downstream from the human synapsin I gene and within the last intron of the A-raf-1 gene has been identified. DNA data-base comparisons of the sequences surrounding the repeat indicate that the synapsin I gene and the A-raf-1 gene lie immediately adjacent to each other, in opposite orientation. PCR amplification of this synapsin I/A-raf-1 associated repeat by using total genomic DNA from members of the 40 reference pedigree families of the Centre d'Etude du Polymorphisme Humaine showed it to be highly polymorphic, with a PIC value of .84 and a ...