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Full-Text Articles in Cell Biology

The Cellular And Molecular Underpinnings Of Intestinal Epithelial Regeneration, Maryam Yousefi Jan 2017

The Cellular And Molecular Underpinnings Of Intestinal Epithelial Regeneration, Maryam Yousefi

Publicly Accessible Penn Dissertations

Injury to the intestinal epithelium is a hallmark of numerous common clinical disorders, including radiation enteropathy, ischemia-reperfusion, and inflammatory bowel diseases. Disruption of the epithelial barrier in these conditions must be quickly restored to avoid dehydration and translocation of gut microbiota to the bloodstream. Short-term calorie restriction can enhance regenerative response of the intestinal epithelium following DNA damaging injury. However, the specific cell type responsible for this enhanced regenerative capacity and as a result the molecular determinants of this process remain unknown.

Regeneration of the intestinal epithelium is driven by multiple intestinal stem cell (ISC) types, including an active, radiosensitive ...


Hdac3 Is A Critical Regulator Of Neural Crest Progenitor Cell Biology, Nikhil Singh Jan 2012

Hdac3 Is A Critical Regulator Of Neural Crest Progenitor Cell Biology, Nikhil Singh

Publicly Accessible Penn Dissertations

Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Specific transcriptional programs regulate the specification, expansion, migration and eventual differentiation of these progenitor cell populations, and tight control of these programs is essential for normal development to occur. Class I histone deacetylases (Hdacs), including Hdac3, play critical roles in regulating gene transcription, through both epigenetic and non-epigenetic means. In this dissertation, I use mouse genetics to explore the previously undescribed role of Hdac3 in regulating neural crest progenitor cell behavior. By genetically deleting Hdac3 in premigratory neural crest cells, I use in vivo and ex vivo techniques ...


Asymmetric T Cell Division And The Self-Renewal Of Specific Immunity, Maria L. Ciocca Jan 2012

Asymmetric T Cell Division And The Self-Renewal Of Specific Immunity, Maria L. Ciocca

Publicly Accessible Penn Dissertations

During clonal selection of a T cell in response to infection of a host with an invasive pathogen, the host must respond by producing at least two required and disparate cell populations - one that is responsible for controlling the current infection and another that is required to retain the T cell clone for protection against future insults. This diversity within the T cell response may be generated through the use of asymmetric cell division. How T cells may use asymmetric division and to what extent this molecular process plays a role in adaptive immunity is not well understood. Here we ...