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Full-Text Articles in Cell Biology

Tissue Retention Of Norrin: A Ligand Required For Retinal Vascularization, Lavan Khandan Jan 2017

Tissue Retention Of Norrin: A Ligand Required For Retinal Vascularization, Lavan Khandan

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

The Norrin ligand is a small (14 kDa) cystine-knot protein, required for the proper vascularization of retinal, cerebellar and inner ear neural tissue. Both inherited human disorders and murine genetic studies implicate Norrin mutations in major ocular and visual defects, including retinal hypovascularization. In this thesis, I describe the property of Norrin enrichment at specific layers in the retina. I address the question of whether proper Norrin distribution in retinal tissue is required for vascularization. To do so, I used ex vivo ligand in-situ staining to interrogate differences amongst vertebrate Norrin orthologues in retinal tissue retention. I then used sequence ...


Dysregulated Fgf And P38 Mapk Signaling Underlies Loss Of Stem Cell Self-Renewal In Aging Skeletal Muscle, Jennifer Delaney Bernet Jan 2013

Dysregulated Fgf And P38 Mapk Signaling Underlies Loss Of Stem Cell Self-Renewal In Aging Skeletal Muscle, Jennifer Delaney Bernet

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Sarcopenia is a geriatric syndrome characterized by loss of skeletal muscle mass, skeletal muscle function and decreased regenerative capacity. A number of skeletal muscle-specific physiological decrements may contribute to sarcopenia; among these is an age-related impairment of satellite cells, the skeletal muscle stem cells required for muscle regeneration. I find that cell-autonomous deficits underlie a loss of self-renewal in aging satellite cells. The decline in self-renewal implicates altered p38αβ mitogen-activated protein kinase (MAPK) activity, which is activated by fibroblast growth factor (FGF) signaling and involved in satellite cell activation, differentiation and self-renewal in young satellite cells. Asymmetric activation of active ...