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GSBS Dissertations and Theses

2011

Centrosome

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The Importance Of The Centrosomal Localization Sequence Of Cyclin E For Promoting Centrosome Duplication: A Dissertation, Joshua J. Nordberg May 2011

The Importance Of The Centrosomal Localization Sequence Of Cyclin E For Promoting Centrosome Duplication: A Dissertation, Joshua J. Nordberg

GSBS Dissertations and Theses

This thesis comprises three separate studies that investigate the consequences of supernumary centrosomes, the effect of centrosome loss, and a control mechanism for regulating CDK2/cyclin E activity in centrosome duplication.

The centrosome is the major microtubule-organizing center of the cell. When the cell enters mitosis, it is of critical importance that the cell has exactly two centrosomes in order to properly segregate the chromosomes to two daughter cells. Supernumary centrosomes are a problem for the cell in that they increase the incidence of chromosomal instability. Aberrant centrosome numbers are seen in a number of cancers, and there has been ...