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University of Wisconsin Milwaukee

Deafness

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Zebrafish As A Model For Determining The Mechanisms Causing Deafness In Myh9-Related Disease, Luke David Spychalla Aug 2014

Zebrafish As A Model For Determining The Mechanisms Causing Deafness In Myh9-Related Disease, Luke David Spychalla

Theses and Dissertations

Approximately 1 in 500 infants are diagnosed with hearing loss, and about half of these cases can be traced to genetic defects. Several hundred genes have been implicated in deafness, including MYH9, which codes for the conventional motor protein non-muscle myosin IIA (NMIIA). Mutations in MYH9 lead to syndromic MYH9-related diseases, which include deafness as a variable symptom, as well as non-syndromic autosomal deafness DFNA17. Despite its identification as a deafness gene, the functions of MYH9 in ear development and hearing remain unknown. To study this role, we will use zebrafish as a model. Zebrafish offer significant advantages including established ...