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Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

University of Wisconsin Milwaukee

2017

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

Histone Deacetylase Inhibition Induces Apoptosis And Cell Cycle Dysregulation In Human And Murine Cancer Cell Lines, Joseph Skurski Aug 2017

Histone Deacetylase Inhibition Induces Apoptosis And Cell Cycle Dysregulation In Human And Murine Cancer Cell Lines, Joseph Skurski

Theses and Dissertations

Carcinogenesis is a complex multistep process that requires tumor cells to grow rapidly while overcoming growth inhibitory signals and sustained challenges from the host immune response. Mutations within promoter or enhancer regions, along with epigenetic changes, can induce aberrant expression of genes that regulate differentiation, cell cycle, and apoptosis, all of which enhance potential for cellular transformation. In recent years, our understanding of the biological processes that influence the activation and repression of transcription have evolved to highlight the role of chromatin architecture, and how chromatin remodeling may be utilized for the potential therapeutic benefit of genetic disease. Histone deacetylase ...