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Mig-10 Functions With Abi-1 To Mediate The Unc-6 And Slt-1 Axon Guidance Signaling Pathways, Yan Xu, Christopher C. Quinn Nov 2012

Mig-10 Functions With Abi-1 To Mediate The Unc-6 And Slt-1 Axon Guidance Signaling Pathways, Yan Xu, Christopher C. Quinn

Biological Sciences Faculty Articles

Extracellular guidance cues steer axons towards their targets by eliciting morphological changes in the growth cone. A key part of this process is the asymmetric recruitment of the cytoplasmic scaffolding protein MIG-10 (lamellipodin). MIG-10 is thought to asymmetrically promote outgrowth by inducing actin polymerization. However, the mechanism that links MIG- 10 to actin polymerization is not known. We have identified the actin regulatory protein ABI-1 as a partner for MIG-10 that can mediate its outgrowth-promoting activity. The SH3 domain of ABI-1 binds to MIG-10, and loss of function of either of these proteins causes similar axon guidance defects. Like MIG-10 ...