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Full-Text Articles in Cell Biology

Direct Regulation Of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) And Feedback Regulation Of Lubac Function By Caspases, Donghyun Joo Aug 2015

Direct Regulation Of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) And Feedback Regulation Of Lubac Function By Caspases, Donghyun Joo

UT GSBS Dissertations and Theses (Open Access)

Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a role in various cellular processes such as proliferation, differentiation (mainly through NF-κB signaling) and death (via apoptosis signaling). Recently, linear ubiquitination by LUBAC (linear ubiquitin chain assembly complex) was reported to have a regulatory function in TNF-α mediated NF-κB activation. Although LUBAC is suggested to control not only NF-kB signaling but also the apoptosis pathway, the precise mechanism of apoptosis regulation remains unknown. Moreover, NF-κB and apoptosis pathways have opposed but fundamental functions for various cellular processes. Although these two pathways actively interplay to balance the death and survival, the ...


The Bbc3 Antisense Intragenic Transcript, Bait, Contributes To Puma Expression By A P53-Autonomous Mechanism, Nicole C. Michael Jan 2015

The Bbc3 Antisense Intragenic Transcript, Bait, Contributes To Puma Expression By A P53-Autonomous Mechanism, Nicole C. Michael

Undergraduate Honors Theses

p53 is a tumor suppressor protein which orchestrates cell cycle arrest or apoptosis to prevent the hyperproliferation of cells which could lead to cancer. However, when p53 is inactivated, which happens in over 50% of cancers, it fails to induce PUMA, a potent apoptotic protein. Loss of PUMA makes cancer cells less likely to undergo apoptosis upon stress stimuli. Recent GRO-seq data revealed unique antisense transcription initiated 6kb into the PUMA locus, creating a small noncoding RNA transcript dubbed BAIT (BBC3 antisense intragenic transcript). This project focused on understanding the expression and function of BAIT, which we hypothesized could modulate ...