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Apoptosis

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

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Full-Text Articles in Cell Biology

Paternal Mitochondria Elimination And Cell Death Regulation In C. Elegans, Qinghua Zhou Jan 2012

Paternal Mitochondria Elimination And Cell Death Regulation In C. Elegans, Qinghua Zhou

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

The nematode C. elegans is a model organism for various biomedical studies due to its genetic simplicity and conservation with humans. As C. elegans is uniquely amenable to cellular, molecular genetic, and biochemical analyses, many basic biological processes are investigated by experimentally manipulating and observing worms. My thesis describes how I used C. elegans models to advance our understanding of paternal mitochondria elimination and cell death regulation.

Mitochondria are membrane-enclosed organelles that carry their own genome (mtDNA). In mammals, the inheritance of mitochondria and mtDNA is strictly maternal, despite the fact that a sperm can inject up to 100 functional ...


Novel Molecular Mechanisms That Modulate The Cellular Response To P53 Activation, Ryan Edward Henry Jan 2012

Novel Molecular Mechanisms That Modulate The Cellular Response To P53 Activation, Ryan Edward Henry

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

The p53 tumor suppressor protein is the most frequently mutated gene in human tumors and is amongst the most intensely studied molecules in modern biology. p53 acts primarily as a stress-responsive transcription factor that directly regulates the expression of over one hundred target genes, the products of which mediate such tumor suppressive responses as cell cycle arrest, apoptosis, senescence and DNA damage repair. It is well established that p53-dependent cellular stress responses can vary, depending on both the nature of the p53-activating stimulus as well as the cell type experiencing the stress; however, the molecular mechanisms that drive cells to ...


The Drosophila Receptor Tyrosine Kinase Tie Instructs Function Of The Bantam Microrna In The Response To Ionizing Radiation, Amber Bilak Jan 2012

The Drosophila Receptor Tyrosine Kinase Tie Instructs Function Of The Bantam Microrna In The Response To Ionizing Radiation, Amber Bilak

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Life or death choices of cells in Drosophila depend on the accumulation of critical levels of pro-apoptotic factors such as hid. Ionizing radiation (IR) causes lesions to macromolecules in cells that trigger damage responses and result in death of cells expressing critical amounts of hid. Cells are eliminated by apoptosis to prevent the transfer of damaged genetic material to daughter cells. However, some cells must be preserved in order for organisms to survive and regenerate. Therefore, genes that limit apoptosis can enhance organismal survival. The ban miRNA limits apoptosis after IR exposure by regulating the 3'UTR of hid. Though ...