Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 3 of 3

Full-Text Articles in Cell Biology

Homothorax Is A Modifier Of Radiation Sensitivity In Drosophila Melanogaster Bantam Mutants, Geoffrey Meyerhof Jan 2017

Homothorax Is A Modifier Of Radiation Sensitivity In Drosophila Melanogaster Bantam Mutants, Geoffrey Meyerhof

Undergraduate Honors Theses

Radiation resistance in human cancers represents a massive impediment for successful tumor treatment. The fruit fly Drosophila melanogaster is an excellent model for human radiation resistance because of its largely conserved apoptotic pathways and malleable genome. This thesis investigates the genetic regulatory mechanisms for bantam (ban), an anti-apoptotic microRNA. To first identify genes that interact with ban, a forward genetic screen was conducted. This screen looked for genes that yielded radiation dependent pupal lethality in a ban deficient background. From this screen the transcription factor, homothorax, was identified as displaying radiation dependent synthetic lethality with ban. To investigate the mechanism ...


Paternal Mitochondria Elimination And Cell Death Regulation In C. Elegans, Qinghua Zhou Jan 2012

Paternal Mitochondria Elimination And Cell Death Regulation In C. Elegans, Qinghua Zhou

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

The nematode C. elegans is a model organism for various biomedical studies due to its genetic simplicity and conservation with humans. As C. elegans is uniquely amenable to cellular, molecular genetic, and biochemical analyses, many basic biological processes are investigated by experimentally manipulating and observing worms. My thesis describes how I used C. elegans models to advance our understanding of paternal mitochondria elimination and cell death regulation.

Mitochondria are membrane-enclosed organelles that carry their own genome (mtDNA). In mammals, the inheritance of mitochondria and mtDNA is strictly maternal, despite the fact that a sperm can inject up to 100 functional ...


The Drosophila Receptor Tyrosine Kinase Tie Instructs Function Of The Bantam Microrna In The Response To Ionizing Radiation, Amber Bilak Jan 2012

The Drosophila Receptor Tyrosine Kinase Tie Instructs Function Of The Bantam Microrna In The Response To Ionizing Radiation, Amber Bilak

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Life or death choices of cells in Drosophila depend on the accumulation of critical levels of pro-apoptotic factors such as hid. Ionizing radiation (IR) causes lesions to macromolecules in cells that trigger damage responses and result in death of cells expressing critical amounts of hid. Cells are eliminated by apoptosis to prevent the transfer of damaged genetic material to daughter cells. However, some cells must be preserved in order for organisms to survive and regenerate. Therefore, genes that limit apoptosis can enhance organismal survival. The ban miRNA limits apoptosis after IR exposure by regulating the 3'UTR of hid. Though ...