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Apoptosis

Cancer Biology

Series

2016

Articles 1 - 2 of 2

Full-Text Articles in Cell Biology

The Beneficial Role Of Extracellular Reactive Oxygen Species In Apoptosis-Induced Compensatory Proliferation, Neha Diwanji, Andreas Bergmann Aug 2016

The Beneficial Role Of Extracellular Reactive Oxygen Species In Apoptosis-Induced Compensatory Proliferation, Neha Diwanji, Andreas Bergmann

Molecular, Cell and Cancer Biology Publications

Apoptosis-induced proliferation (AiP) maintains tissue homeostasis following massive stress-induced cell death. During this phenomenon, dying cells induce proliferation of the surviving cells to compensate for the tissue loss, and thus restore organ size. Along with wound healing and tissue regeneration, AiP also contributes to tumor repopulation following radiation or chemotherapy. There are several models of AiP. Using an "undead" AiP model that causes hyperplastic overgrowth of Drosophila epithelial tissue, we recently demonstrated that extracellular reactive oxygen species (eROS) are produced by undead epithelial cells, and are necessary for inducing AiP and overgrowth. Furthermore, hemocytes, the Drosophila blood cells, are seen ...


Er Stress In Temozolomide-Treated Glioblastomas Interferes With Dna Repair And Induces Apoptosis, Jessica L. Weatherbee, Jean-Louis Kraus, Alonzo H. Ross Jun 2016

Er Stress In Temozolomide-Treated Glioblastomas Interferes With Dna Repair And Induces Apoptosis, Jessica L. Weatherbee, Jean-Louis Kraus, Alonzo H. Ross

Open Access Articles

Glioblastoma multiforme (GBM) is a deadly grade IV brain tumor. Radiation in combination with temozolomide (TMZ), the current chemotherapeutic for GBMs, only provides 12-14 months survival post diagnosis. Because GBMs are dependent on both activation of the DNA damage pathway and the endoplasmic reticulum (ER) stress response, we asked if a novel ER stress inducing agent, JLK1486, increases the efficacy of TMZ. We found that the combination of TMZ+JLK1486 resulted in decreased proliferation in a panel of adherent GBM cells lines and reduced secondary sphere formation in non-adherent and primary lines. Decreased proliferation correlated with increased cell death due ...